![]() The hyperthyroid condition itself does not impact directly on the accumulation of connective tissue within the orbit ( 1, 2). ![]() ![]() The close association of TED with Graves' disease of the thyroid provides clues to its etiology. Understanding the pathogenetic mechanisms underlying TED should yield the identification of predictive biomarkers of progressive disease and effective and specific treatments. They do nothing to prevent or reverse pathological remodeling of orbital tissues ( 10). These interventions are aimed at the consequences of the disease rather than targeting its cause, which remains poorly understood ( 5, 6, 10, 11). Current therapeutic options include corticosteroids, external beam radiation, and surgery. To date, there are no effective means of preventing the disease or reliably altering its course. The increased volume of orbital connective tissue leads to protrusion of the eye (exophthalmos) ( 2, 9). The most dramatic pathological findings in end-stage TED include glycosaminoglycan (GAG) deposition (accompanied by dramatic swelling resulting from the water-binding capacity of these macromolecules) and fibrosis affecting the extraocular muscles and fat accumulation in the orbit ( 5– 8). TED affects many eye functions, including wetting of the ocular surface, eye motility, optic nerve function, and eyelid anatomy ( 2, 5). TED occurs more frequently in patients older than 50 years of age and in males, smokers, and those with microvascular disease ( 2, 4). Besides hyperthyroidism, up to 60% of patients with Graves' disease develop a manifestation localizing to the orbit called Graves' ophthalmopathy or thyroid eye disease (TED) ( 2, 3). ![]() G raves' disease is an autoimmune condition in which the thyroid-stimulating hormone receptor (TSH-R) displayed on thyrocytes is targeted by autoantibodies, inducing the production of excess thyroid hormone ( 1). Although the mechanisms underlying these processes are not completely understood, several currently available therapeutic strategies might interrupt the signaling between B and T cells and fibroblasts, thereby treating the clinical manifestations of TED. These interactions ultimately result in fibroblasts expressing extracellular matrix molecules, proliferating and differentiating into myofibroblasts or lipofibroblasts. When orbital fibroblasts are activated, possibly by Graves' disease–related autoantibodies, they release T cell chemoattractants, initiating an interaction in which these cells activate each other. Recent findings have uncovered the importance of intercellular communication between autoreactive T cells and orbital fibroblasts. Such treatments may become available as a result of research aimed at understanding the mechanism by which Graves' disease leads to specific remodeling of orbital tissues. Current treatments are sometimes effective in alleviating the symptoms of the disease, but there remains a demand for treatments that prevent or reverse the pathological alterations of orbital tissues. This dramatic remodeling results in protrusion of the eye, also known as exophthalmos. During the course of TED, fibrosis can develop around the extraocular muscles, and excess extracellular matrix and fat accumulates in the periorbital space. Thyroid eye disease (TED) is an inflammatory condition of the orbit closely associated with Graves' disease. ![]()
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![]() ![]() I was a little confused but I thought I would go with it to see what happened. And then it had me take the next offramp and I was on city streets. I noticed that the 5 was at a dead stop at the intersection. However at a certain section when I had the option to choose the 101 or the five freeway it had me take the 101. And The route that I chose had me go through the five freeway. Today I was coming home from Santa Fe Springs California to Ventura California. The others only default to the one option and you get what you get. I can then see which route has the least traffic and select that one. I like MapQuest better than the system in my car or Google maps because it gives me the option of 2 to 3 different routes to take. If there was less that one star review, that would be my review of Mapquest. ![]() It’s gotten so bad that at times I just use google maps or another app so I can actually get to where I’m going safely. Mapquest is a vehicle accident waiting to happen! I’ve deleted, re-added this app several times and it still doesn’t work properly. Every time I go to get on I90 the directions never tell me which direction E or W, it always says it’s going to be on the left when both ramps are on the right. The map and instructions do not advance and so while driving, you have to manually advance it so you can have an accurate and up to date idea of where you are in your route. So instead of watching the road ahead, you are now forced to look for signs to tell you the CR. So instead of focusing on the road and driving, you have to guesstimate what 100įeet is because the app can’t be bothered to tell you the actual street name! Many street names are replaced with CR and a number as if anyone goes by the CR. Street names have been replaced by turn right in 100 feet. When it does (rarely) it waits to tell you when you are within 100 feet of your turn that you are supposed to turn (by cutting across 2-4 lanes to then get into the proper turn lane… ridiculous. All in all, gonna try to use Mapquest in my car while driving more often than Apple Maps. Google maps does better on a laptop for research if you’re looking into greater details for research of cities, driving distance, businesses in the area or trying to google drive in their map system to see what an area looks like virtually to plan your move or road trip in general. Plus Apple Maps is a pain because it automatically switches routes on you as you drive further into your 1st route that you picked and it’s stressful! When I’m driving I know that I picked route #1 option and refused route 2 or 3 for reasons but Apple Maps will automatically switch the route even when you are trying to exit off or onto a freeway or major intersection which is dangerous!!! It never used to be like that. Google maps is difficult to do any of those finger gestures which is a pain when you are driving in the moment. I can use my fingers to pinch and move the map around in circles, side ways etc like Apple Maps that’s in my iPhone. Please Note: Continued use of GPS running in the background can dramatically decrease battery life. View local weather so you can plan ahead.Save money by comparing prices of nearby gas stations.Feed your inner foodie and discover new places to eat: browse menus, make reservations and order food through OpenTable and GrubHub points of interest.Find great hotel deals and book them directly from within the MapQuest: Maps & GPS Navigation app.Search and explore nearby points of interest like restaurants, bars, gas stations and hotels, with our layers bar.Planning: create routes starting from somewhere other than your current location.Multipoint routes so you can include more than just one stop.Route options that help you avoid things like highways and toll roads.Route choices so you have more suggestions to get where you need to go faster.Favorites so you can store locations, like your home and work addresses, for quick-and-easy maps and directions. ![]()
![]() ![]() Connected devices, and settings such as brightness, can also drain the battery. ![]() For example, some apps-such as video editing software and video games-can require more power and drain the battery more quickly. Your Mac laptop may not be charging because of a high performance level, the software, or Battery health settings.Īvoid draining the battery quickly: Your computer may be running at a very high performance level that uses more power than the power source provides. Get started with accessibility features.Use Sign in with Apple for apps and websites.Watch and listen together with SharePlay.Share and collaborate on files and folders.Sync music, books, and more between devices.Make and receive phone calls on your Mac.Use one keyboard and mouse to control Mac and iPad.Use Live Text to interact with text in a photo.Make text and other items on the screen bigger.Install and reinstall apps from the App Store.If you need help, you can call Dave’s Computers at (908) 304-9760 or message us here. If you have an older desktop that doesn’t use Apple silicon or the Apple T2 Security Chip, follow these steps. If you need help reach out at Dave’s Computers. Let go of all four keys, and then turn on your computer but pressing the power button.While holding all three keys (Shift, Control, and Option), press and hold the power button as well for 10 seconds. ![]()
![]() ![]() Its claims departments and home office staff regularly receive excellent marks for customer service. When it comes to customer service, Lincoln Heritage has a bit of a Dr. That’s why it’s always a good idea to compare life insurance quotes from a variety of providers. In most cases, if you are willing to do the leg work, you can find a policy for a lower rate than Lincoln Heritage even with a challenging health condition. While not every insurer covers every health condition, you can still probably find at least a few insurance policies that will cover your specific condition. Customers with health conditions are likely to be placed on Lincoln Heritage’s modified plan with a waiting period, and they will almost certainly pay a hefty premium for their coverage. Lincoln Heritage stands apart from the pack in that it’s willing to cover a much wider range of health issues than most insurers. This may be because Lincoln Heritage doesn’t require its customers to submit to a medical exam.Įvery life insurer has different standards for what health conditions it will cover and which conditions it won’t. What’s even more surprising is that Funeral Advantage rates for customers with health issues tend to be significantly higher than what competitive policies offer. You can also purchase these riders as individual policies from other insurers, so it’s always a good idea to compare prices before committing. A sales agent may be able to make these riders sound indispensable, but they will add to your monthly premium. (If you’d prefer an even higher benefit-perhaps to pay down a mortgage or make sure the kiddos get through college-take a look at these alternative life insurance policy options.)Īdditionally, Lincoln Heritage also offers a child rider, which offers a payout if a biological, adopted, or stepchild should pass away.īe careful before signing onto one of these riders. You can choose to purchase up to five units of add-on coverage, meaning your accidental death or dismemberment rider could pay a maximum of $100,000 in certain situations. ![]() Depending on the nature of the accident or dismemberment you experience, your policy could pay an additional $5,000 to $20,000 per unit you add. In this scenario, your final expense insurance payout will be the perfect amount to cover your funeral cost or send those last medical bills packing.īut what happens if you are cut down in the prime of life when your family still has bills to pay? Lincoln Heritage offers a rider, called accidental death and dismemberment coverage, for this scenario. The house will be paid off, diplomas will hang on the walls in your children’s homes, and a nest egg will be waiting in your investment accounts. By the time your final expense insurance policy pays out, hopefully you’ll have lived a long and fulfilled life. ![]() ![]() ![]() Several areas are closed to all fishing to protect snappers and groupers, including gag.
![]() The Mujahideen then betray the Americans and Zhao, leaving them to die in the Afghan wilderness until their rescue by two unidentified civilians. They locate Lev Kravchenko, who survived the grenade explosion in Vietnam with Woods, and interrogate him about Menendez's plans before executing him. The trio and Chinese operative Tian Zhao ally with the Afghan Mujahideen against the Soviets. ![]() Later in the year, the CIA authorizes a strike against the unscrupulous Nicaraguan, now making a healthy profit running arms across Soviet-occupied Afghanistan. In light of this information, Mason, Woods, and Hudson begin tracking Menendez, who has established himself as a primary arms dealer for bush conflicts in Southern Africa and Latin America. It is revealed that Menendez is responsible for holding Woods captive after murdering his team. ![]() However, a firefight breaks out, and their quarry escapes as the Americans are rescued by helicopter. With UNITA's assistance, Mason and Hudson recover Woods from the Cubango, subsequently locating Menendez among a contingent of Cuban military advisers. Woods had disappeared with his men while aiding Jonas Savimbi's UNITA rebels against Angola's Marxist government their actions have already been disavowed by the CIA and Hudson hopes to rescue any survivors. Their shaky relationship is strained further when Mason is solicited by his former handler Jason Hudson, seeking to recruit him for an assignment in Cuando Cubango during the height of the Angolan civil and South African Border Wars. ![]() Frank then narrates several covert missions undertaken during his military career which span their previous encounters.Īccording to Woods, by 1986 Alex Mason had effectively retired from active duty to pursue an obscure existence in Alaska with his son, the seven-year-old David. Woods concedes that Menendez has recently visited him, and shows them a locket that the latter had left behind. special operations team led by David Mason and his partner, Mike Harper, arrive at " The Vault", a top-security location home to an aging Frank Woods, whom they suspect possess vital information on the whereabouts of Raul Menendez. Whilst it continues the saga of certain main characters introduced in the original Black Ops, both arcs take place several decades after the conclusion of the first game. The story takes place across two separate arcs, one recounting events in 1986-1989, a few years after the events of Call of Duty: Black Ops Cold War and 18 years after Mason stops Dragovich and Nova 6, and the other following characters in the year 2025. 14.3 Digital Deluxe Edition (PC Exclusive).The link to the Call of Duty: Black Ops II website was also granted access to the public to coincide with the world reveal during the NBA basketball playoffs.Īfter much demand, anticipation, and speculation, Call of Duty: Black Ops II finally became available on Xbox One via backwards compatibility on April 12, 2017. The game is also the first Call of Duty game for Nintendo's Wii U console, and it was available for the Wii U's launch day in North America, Europe, and Australia, whilst it was released on Decemin Japan, which was 12 days after the console's Japanese launch day, albeit the console received the Japanese dub version simultaneously with the other platforms on the same day. It is the first game made by Treyarch to be set in the future, and also the first direct sequel produced for the series by the studio. It is the direct sequel to Call of Duty: Black Ops and was announced on May 1, 2012, during an NBA playoff game. ![]() This is the ninth main installment for the Call of Duty franchise, as well as being the first Call of Duty game available to an 8th generation console (Wii U), and was released on November 13, 2012. Wii U " THE FUTURE IS BLACK." - Official tag lineĬall of Duty: Black Ops II, is a first-person shooter developed by Treyarch and published by Activision. ![]() ![]() ![]() PaintTool SAI License Key pay attention to the expired date. It should be noted that the developer does not provide technical support However, it is easy to find online tutorials. PaintTool SAI Full Version License Key since image processing is not the focus of this program, there are only two picture settings: Brightness / Contrast and Hue / Saturation. 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Paint Tool Sai Crack, Paint Tool SAI Mac download it to the direct link given below, where you can simply click and download Paint Tool Sai free of charge. ![]() ![]() ![]() But Mayfield threw a pass that was deflected and intercepted by Brown. ![]() ![]() The Bucs forced a quick punt and were in position to cut into that even more on the next possession when they drove to the San Francisco 12.īut Mayfield then threw incomplete passes on the next two downs - including a near interception - before being pressured on a fourth-down blitz that ended with another incomplete pass to Mike Evans in the end zone with rookie Ja'Ayir Brown in coverage.Ī forced three-and-out and a long punt return gave Tampa Bay another shot at the San Francisco 9. Tampa Bay had cut a 20-point deficit to 13 on a 1-yard run by Rachaad White in the opening minute of the fourth quarter. The offense didn't have much success until late, but the Bucs still had a chance to make things interesting in the fourth quarter. Police say Gibson pushed her inside, took about $300 and shot her in the head, a killing also captured on surveillance video.The run game never got going once again and Mayfield lost a fumble to thwart one promising drive in the first half. ![]() Almansoori survived and testified in Gibson’s trial.Īlmansoori was shot one day after Wright was killed in his Wilmington residence, which prosecutors say was a known “drug house.” Gibson was later found with a shoulder bag in which prosecutors say Wright kept his drugs.Įarlier on the same day Wright was shot, Christine Lugo, 40, was confronted by a gunman as she opened a Dunkin’ shop in north Philadelphia. As he leaves, the gunman turns and shoots Almansoori again. After stealing several items, the gunman shoots the prone teenager in the head. The stolen vehicle was later recovered in Philadelphia near Gibson’s home.Īlmansoori, who was shot on June 6, 2021, is seen lying on the floor of his store pretending to be dead after a gunman’s first shot missed him. He then walks out of the store with stolen cash and cell phones and drives away in her SUV. As Ruiz-Basilio has her arms raised, the gunman raises his weapon and shoots her in the head at point-blank range. Surveillance footage from May 15, 2021, at the Metro PCS store in Elsmere shows Ruiz-Basilio being confronted by a gunman, who takes her to the back of the store. They also argue that ballistics evidence links the shootings of Ruiz-Basilio and Wright and ties them to a revolver recovered when Gibson was arrested. Prosecutors in Delaware have relied heavily on video surveillance footage showing the robberies and shootings of Ruiz-Basilio and Almansoori. Authorities say they will pursue those charges after Gibson is prosecuted in Delaware. The Philadelphia district attorney, meanwhile, has approved murder charges against Gibson in the killings of his mother and a Philadelphia doughnut shop manager, as well as the deaths of two men found shot in the head at a store in Philadelphia’s Germantown neighborhood. He is also charged with attempted murder in the shooting of Wilmington store clerk Belal Almansoori, and the armed robbery of a drug store. Keith Gibson, 41, of Philadelphia, is charged with murder in the killings of Elsmere cellphone store clerk Leslie Ruiz-Basilio, 28, and Wilmington drug dealer Ronald Wright, 42, during separate robberies. (AP) - A Delaware jury heard closing arguments and began deliberations Monday in the trial of a suspected serial killer accused in the deaths of six people in Delaware and Pennsylvania in 2021. ![]() ![]() ![]() Bringing our companies together paves the way for amazing developments which our customers will love.”įollowing this, at the Worldwide Developers Conference in June 2014, Cook announced the latest version of the Apple operating system for desktop and mobile, OSX Yosemite. In a letter to Apple employees, Cook said, “This afternoon we announced that Apple is acquiring Beats Music and Beats Electronics, two fast-growing businesses which complement our product line and will help extend the Apple ecosystem in the future. ![]() ![]() Dre and Jimmy Iovine would join Apple in executive roles. As part of the deal, Beats co-founders Dr. In May 2014, Apple announced its biggest acquisition to date when it bought Beats Music and Beats Electronics for $3 billion. In addition to serving as CEO, Cook sits on the corporation's board of directors. In August 2011, Cook was named Apple's new CEO, taking over the position for former CEO and Apple co-founder Steve Jobs, who died in October 2011 after a years-long battle with cancer. As Cook rose to executive vice president and then chief operating officer, he took responsibility for managing worldwide sales and operations, along with leading the Macintosh division and continued development of reseller/supplier relationships. Less than a year after his Apple debut, the corporation was reporting profits, an extraordinary shift from a recent report that showed a net loss of $1 billion from the prior fiscal year. "Only a few months before I'd accepted the job at Apple, Michael Dell, the founder and CEO of Dell Computer, was publicly asked what he would do to fix Apple, and he responded, 'I'd shut it down and give the money back to the shareholders.'"īut things quickly changed after Cook came on board as a vice president. "While Apple did make Macs, the company had been losing sales for years and was commonly considered to be on the verge of extinction," he told the Auburn graduates. According to Cook, prior to accepting his job at Apple, he was actually dissuaded from doing so on the grounds that the company's future looked very bleak. However, it wasn't an easy decision: Cook began working for Apple in early 1998, before the company had developed the iMac, iPod, iPhone or iPad, and when it was seeing declining profits instead of profit growth. "My most significant discovery so far in my life was the result of one single decision: My decision to join Apple," Cook stated some 12 years after joining the corporation, while speaking at Auburn University's commencement ceremony in 2010. His time there was short-lived, however: After a six-month stint at Compaq, Cook left for a position at Apple. After three years, he joined the Compaq Computer Corporation as vice president of corporate materials, charged with procuring and managing product inventory. ![]() He was hired by IBM, where he moved up the ranks to become the corporation's North American fulfillment director, managing manufacturing and distribution functions for IBM's Personal Computer Company in both North and Latin America.įollowing a 12-year career at IBM, Cook in 1994 became the chief operating officer of the Reseller Division at Intelligent Electronics. Early Careerįresh out of graduate school, Cook embarked on a career in the field of computer technology. Additionally, Cook was awarded the title of Fuqua Scholar-an honor given only to students at the business school who graduate in the top 10 percent of their class. He enrolled at Auburn University in Alabama, graduating in 1982 with a bachelor's degree in industrial engineering, and went on to earn a Master of Business Administration degree from Duke University's Fuqua School of Business in 1988. The middle of three sons born to father Donald, a shipyard worker, and mother Geraldine, a homemaker, Cook attended Robertsdale High School and graduated second in his class in 1978. Cook in the small town of Robertsdale, Alabama, on November 1, 1960. In August 2011, Cook was named Apple's new CEO, following the death of predecessor Steve Jobs. Following a 12-year career at IBM, Cook went on to executive roles at Intelligent Electronics and Compaq, before joining Apple in 1998. Apple CEO Tim Cook graduated from Auburn University with a bachelor's degree in industrial engineering and earned an MBA from Duke University's Fuqua School of Business. ![]() ![]() ![]() Orders placed by other means will have additional transaction costs. Spreads, Straddles, and other multiple-leg option orders placed online will incur $0.65 fees per contract on each leg. Prior to trading options, you should carefully read Characteristics and Risks of Standardized Options. Options are not suitable for all investors as the special risks inherent to options trading may expose investors to potentially rapid and substantial losses. That seemed a bit strange after spending so much time describing the 10/50 SMA system, and its not really clear how the two sets of moving averages play together. In the second trade, price hits 3x target, and breaking the Hull avg would close the trade. In the Google Docs presentation, on slide 20, he talks about his particular strategy and introduces a 9/30/50 EMA crossing strategy for entries and exits. The most popular of those being the 50 day vs 200 day moving average crossover, more commonly known as the death cross or golden cross. ![]() Closing below the Hull average would close the trade. Many traders will use the crossover of two moving average lines as a buy or sell signal. Trading foreign exchange on margin carries a high level of risk, as well as its own unique risk factors. In the first trade, price goes above the 200 EMA and hits the 2x target. ema in thinkorswim download Finviz Premarket Finviz Elite users have access to. Clients must consider all relevant risk factors, including their own personal financial situation, before trading. Another day-trading method is to do some. Trading stocks, options, futures and forex involves speculation, and the risk of loss can be substantial. The final result is the difference between two first EMAs multiplied by 3 plus the third EMA. Three EMAs are calculated consequently: EMA of price, EMA of the first EMA, and EMA of the second EMA. Past performance of a security or strategy is no guarantee of future results or investing success. The Triple Exponential Moving Average is technical indicator used for averaging fundamental data. Market volatility, volume and system availability may delay account access and trade executions. This is not an offer or solicitation in any jurisdiction where we are not authorized to do business or where such offer or solicitation would be contrary to the local laws and regulations of that jurisdiction, including, but not limited to persons residing in Australia, Canada, Hong Kong, Japan, Saudi Arabia, Singapore, UK, and the countries of the European Union. moving average crossover but added scanner cloud and alerts for additional. Not a recommendation of a specific security or investment strategy.ĭo Not Sell or Share My Personal Information EMA crossover is your strategy then this indicator plot an up arrow on the. The type of the second moving average: simple, exponential, weighted, Wilder's, or Hull.ĭefines whether to display a signal when the first moving average crosses above or below the second one. The type of the first moving average: simple, exponential, weighted, Wilder's, or Hull. The number of bars used in calculation of the second moving average. The number of bars used in calculation of the first moving average. ![]() It is considered a Buy signal when the short average crosses above the long one Sell signal, if the long average surpasses the short one. The general idea of moving average-based analysis is combining two moving averages with different lengths: short and long. The following moving averages can be used: simple, exponential, weighted, Wilder's, or Hull. Test your trading skills on a 25,000 or 50,000 virtual account Pass the exam, get funded and. There are numerous other factors related to the markets in general or to the implementation of any specific trading program which cannot be fully accounted for in the preparation of hypothetical performance results and all which can adversely affect trading results.Moving Average Crossover is a study which helps you find crossovers of moving averages of different types and lengths. For example, the ability to withstand losses or to adhere to a particular trading program in spite of trading losses are material points which can also adversely affect actual trading results. In addition, hypothetical trading does not involve financial risk, and no hypothetical trading record can completely account for the impact of financial risk of actual trading. One of the limitations of hypothetical performance results is that they are generally prepared with the benefit of hindsight. No representation is being made that any account will or is likely to achieve profits or losses similar to those shown in fact, there are frequently sharp differences between hypothetical performance results and the actual results subsequently achieved by any particular trading program. Hypothetical Performance Disclosure: Hypothetical performance results have many inherent limitations, some of which are described below. ![]() |
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